World leaders called on Iran and Israel to try to avoid escalating tensions following the apparent Israeli airstrike on Friday near an Iranian air base and nuclear facility.

Group of Seven foreign ministers meeting in Italy warned of new sanctions against Iran for its drone and missile attack on Israel last weekend, and urged both sides to avoid worsening the conflict.

Meanwhile, an apparent Israeli strike on Iran saw troops fire air defenses near the central city of Isfahan. It came days after Tehran’s unprecedented drone-and-missile assault on Israel.

Israel also carried out a missile strike on an air defense unit in southern Syria, causing material damage, Syria’s state-run SANA news agency said, citing a military statement.

Israel had vowed to respond to Iran’s weekend attack.

Regional tensions have increased since the start of the latest Israel-Hamas war on Oct. 7, when Hamas and Islamic Jihad — two militant groups backed by Iran — carried out a cross-border attack that killed 1,200 people in Israel and kidnapped 250 others. Israel responded with an offensive in Gaza that has caused widespread devastation and killed more than 33,900 people, according to local health officials.